What’s in a rat?

The role of rodents in biomedical research is invaluable. Rodents, such as mice and rats, are the most commonly used mammals in biomedical research because of their anatomical, physiological and genetic similarities to humans. 

Scientists are able to genetically adapt mice to study a disease, for example by removing certain genes or by inserting (human) genes that are at the basis of certain disorders. For example, breast cancer can be simulated in mice to study the mechanisms of cancer and to test treatments. Mice and rats are also often used in behavioral studies to test, for example, treatments for memory loss in dementia.

Rodents are used in countless research areas, from cancer to immune diseases, heart disease, hypertension, metabolic and hormonal disorders, diabetes, obesity, osteoporosis, glaucoma, blindness, deafness, psychiatric disorders such as depression and schizophrenia, and neurodegenerative disorders such as Alzheimer's disease, Parkinson's and ALS.

The images taken with the new Moticam S6 camera show a cross-section with details through the upper body of the rat, just above the splice of the trachea into the two bronchi. The beautiful coup shows the various body parts in this cross section, some of which are indicated below.

With thanks to Cees Koopman, veterinarian.

© willemsmicroscope.com

Trypanosoma cruzi

Trypanosoma cruzi is a single-celled parasite, first described in 1909 by the Brazilian physician Carlos Chagas, and the causative agent of Chagas disease. It is a tropical vector disease that occurs in humans, among others, and mainly in South America.

Lick granuloma dog

A lick granuloma or acral lick dermatitis is a place on the skin as a result of frequent licking by the dog and is found usually at the end of the paws, hence acral (think of the Athenian Acropolis: city on top) Lesion is sharply defined. This is a nasty ailment. It is not always clear what causes it, but itching is often the reason. A physical cause is rarely found. Usually the cause is psychological such as boredom, separation anxiety, stress, nervousness or attention seeking behavior. Licking is then a distraction for the dog. Once the dog is licking, it is difficult to stop this. It has become a habit for the dog.

The first symptoms are discoloration of the coat due to the saliva. The skin can become thicker and bald. Inflammation of the skin is possible due to the granuloma. This starts itching more and makes the dog more lick and bite. Then the dog comes in a vicious circle. The process can continue down to the bone, sometimes amputation is necessary. A lick granuloma actually only occurs on the front legs.

Malaria

Malaria has been recognized since the Greek and Roman civilizations over 2,000 years ago, with different patterns of fever described by the early Greeks. Malaria is the most important tropical disease known to man. It remains a significant problem in many tropical areas, especially in sub-Saharan Africa. Malaria is spreading as a result of environmental changes, including global warming, civil disturbances, increasing travel and drug resistance. There are approximately 100 million cases of malaria worldwide with about 1 million of these proving fatal.

Pear rust and Junipers

Pear Rust is an increasingly common fungal disease in pear trees. This disease can significantly slow the growth of a pear tree, and the tree will also give less fruits. Pear Rust is a fungus that cannot stay the whole year on the pear: in winter the tree has no leaves and the fungus is only present there. In winter, the fungus needs a Juniper to overwinter. After the winter the fungus makes spores, which are spread through the air. The spores fall on the pear tree, causing the fungal disease.