Thursday 6 July 2023

What’s in a rat?

The role of rodents in biomedical research is invaluable. Rodents, such as mice and rats, are the most commonly used mammals in biomedical research because of their anatomical, physiological and genetic similarities to humans. 



Scientists are able to genetically adapt mice to study a disease, for example by removing certain genes or by inserting (human) genes that are at the basis of certain disorders. For example, breast cancer can be simulated in mice to study the mechanisms of cancer and to test treatments. Mice and rats are also often used in behavioral studies to test, for example, treatments for memory loss in dementia.

Rodents are used in countless research areas, from cancer to immune diseases, heart disease, hypertension, metabolic and hormonal disorders, diabetes, obesity, osteoporosis, glaucoma, blindness, deafness, psychiatric disorders such as depression and schizophrenia, and neurodegenerative disorders such as Alzheimer's disease, Parkinson's and ALS.

The images taken with the new Moticam S6 camera show a cross-section with details through the upper body of the rat, just above the splice of the trachea into the two bronchi. The beautiful coup shows the various body parts in this cross section, some of which are indicated below.





With thanks to Cees Koopman, veterinarian.
© willemsmicroscope.com


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