A fibrosarcoma is a malignant tumor of mesenchymal connective tissue cells. Fibrosarcoma mainly occurs as a solitary tumor in the older cat. It can occur in several parts of the body. Usually on the trunk and often also between the shoulder blades, because injections are usually given here. First there is an injection site reaction that degenerates neoplastic. The rabies vaccine is known to be a possible cause of this. It is a malignant derailment of the dermal and subdermal connective tissue cells. The sarcoma grows locally very infiltratively and aggressively, not metastasizing quickly. But if so, then to the lungs and lymph nodes. Fibrosarcoma can also occur in young cats. In these cases it is often induced by a virus and there are multiple tumors over the entire body.
A fibrosarcoma is recognized by a wavy braided cell structure of the elongated cells whose ends are tapered (spindle cells) Histologically it is a confused image (like turbulent bars or like a painting by Van Gogh) The cells have atypical nuclei (shape / color / mitosis) with sometimes multiple nucleoli. Fibrosarcomas feel firm or fleshy, are irregular in shape, often nodular with offshoots.
A final diagnosis is made by the veterinarian after taking biopsies. With X-rays you can examine whether there are metastases. The treatment consists of radical, very large resection, because otherwise the malignant tissue can quickly grow back by remaining cells. Optionally, the resection can be followed by radiation.
With thanks to Cees Koopman, veterinarian.
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