Colloid goiter is a benign lesion of the thyroid gland which is defined as thyroid enlargement without accompanying disturbance in thyroid function.
This is a common pathology, frequently found in clinical practice during a physical or ultrasound examination.
Therefore, the Colloid goiter of the thyroid is a benign growth. Nodular formations can be multiple or single instances. Formation is formed when the outflow of a colloidal substance from the follicles is disrupted. Thyroid hormones are produced in this liquid substance.
The tissue we see in the images is always recognizable, because there is nothing else in the body that looks like this. Follicles surrounded by an epithelial lining filled with protein material called colloid.
Fig 1. - Colloid goiter, Thyroid c.s. | Motic BA40E PlanApo 10X |
Moticam S12, ROI | Image credit: Willem Cramer
Most normal thyroid glands have follicles that are fairly uniform in size with some variation. They don't get as big as some in the images. If the follicles are so enlarged by the colloid, you can speak of colloid goiter. What is the definition of the word goiter. This word is synonymous with an enlarged thyroid gland, enlarged for any reason. This does not automatically mean that the thyroid gland is overactive or neoplastic.
Fig 2. - Colloid goiter, Thyroid c.s. | Motic BA40E PlanApo 40X |
Moticam S12, ROI | Image credit: Willem Cramer
If the affected thyroid can also be clinically associated with hyperthyroidism, which is an overproduction of thyroid hormones, then it could be a case of Graves' disease.
The photos show that the enlarged follicles are lined with relatively cube-shaped follicular or epithelial cells.
Sample: Colloid goiter, Thyroid c.s. Motic BA410E PlanApo 40X | Moticam S12 ROI. With thanks to Herbert Spoon, Doctor of Medicine.
Note: the prepared slide, a collector’s item, is 60 years old.
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